Principal Software Engineer I

Keystone AI , a part of Thermo Fisher Scientific, is seeking an experienced Principal Software Engineer I to strengthen our global clinical research technology platforms. This role is responsible for driving robust software deployments, infrastructure automation, and DevOps best practices that support scalable, secure, and compliant systems. By partnering closely with engineering, IT, and operations teams, this position helps accelerate evidence generation and decision‑making across clinical trials worldwide. What We Offer Competitive compensation Medical, dental, and vision insurance beginning Day 1 of employment Flexible work schedules Attractive PTO plan Engaging employee programs Remote working What You’ll Be Doing Design and develop software application deployments. Implement full CI/CD pipelines and automate deployment workflows. Create and run automated testing routines to ensure stable, error‑free deployments. Support DevOps initiatives by automating manual release and build processes. Develop and manage infrastructure automation and cloud environments (AWS, Azure). Train IT and development teams on infrastructure automation best practices. Monitor and maintain software security, performance, and SLAs. Provide Tier III support and ensure optimal application functionality. What We Look For Bachelor’s degree in Computer Science, Software Engineering, or related field. Minimum of 8+ years of professional software development experience. Proven, hands-on experience with .NET, C#, and strong experience with ASP.NET MVC at a senior or principal level. Strong background in SQL, PL/SQL, and Postgres (backend database focus). Experience leading and managing Software Engineering teams, including mentoring engineers, driving technical excellence, and overseeing project delivery. Demonstrated ability to build, coach, and develop high-performing engineering teams in a collaborative environment. Experience conducting requirement analysis and writing unit test cases. Ability to work in Agile development environments. Exposure to CI/CD tools (e.g., Git, Jenkins) is a plus but not required. Excellent documentation and communication skills. Experience in regulated environments (e.g., pharmaceuticals, healthcare) is a plus. Based in or able to work from the United States (remote/hybrid/on-site). At Keystone AI , our purpose is to transform lives by unlocking better evidence. It’s a cause that unites and inspires us. It’s why we come to work—and how we empower our people to make a positive impact every day. Whether you're advancing clinical science, building innovative technology, or supporting our global teams, your work helps bring life‑changing therapies to patients faster. Keystone AI is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. Originally posted on Himalayas